Воздействие высокоэнергетичной протонной компоненты космических лучей на структуру ДНК Котб Омар Махмуд Эльсайед

Краткое описание

Котб, Омар Махмуд Эльсайед.
Воздействие высокоэнергетичной протонной компоненты космических лучей на структуру ДНК : диссертация ... кандидата физико-математических наук : 01.04.16 / Котб Омар Махмуд Эльсайед; [Место защиты: ФГБОУ ВО «Санкт-Петербургский государственный университет»]. - Санкт-Петербург, 2020. - 275 с. : ил.; 14,5х20,5 см.
Оглавление диссертациикандидат наук Котб Омар Махмуд Эльсайед
TABLE OF CONTENTS Introduction
1. Literature review
1.1. Space research
1.1.1. Space exploration and cosmic radiation
1.1.2. Possibilities of modeling primary cosmic radiation in terrestrial conditions
1.2. Proton therapy
1.2.1. Comparison between proton therapy and conventional photon radiation therapy
1.2.2. Proton therapy on a proton beam of energy 1 GeV (PNPI SC-1000 MeV)
2. Irradiation and dosimetry of biological samples with a proton beam of 1 GeV and gamma rays
2.1. DNA irradiation on the medical beam of PNPI synchrocyclotron
2.2. Irradiation of DNA with gamma rays at the NRC KI (PNPI)
3. The effect of ionizing radiation on DNA (review)
3.1. Energy absorption of ionizing radiation
3.2. DNA structure
3
The cell cycle and radiation cell death.
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3.4. Direct and indirect action of radiation
3.5. Radiation damage in the DNA structure
3.6. The effect of cosmic radiation on biological systems
4. Material and methods
4.1. Material
4.2. Spirin method
.4.3 DNA melting
4.4. Circular dichroism (CD)
5. Results and discussion
5.1. Application of spectral methods for determining the radiation damage in the DNA structure
5.2. Comparison of the effect of high-energy protons and gamma rays on the structure of DNA
5.3. The effect of catechin in the process of DNA damage by high-energy protons and y-radiation
Conclusion
List of abbreviations and symbols
References